Gender and sexuality can be fluid, and today transgender issues are altering the nature of day-to-day interactions. What do you do when your seven-year-old son announces that he wants to be a girl? Or your husband of 30 years announces that he wants to be a woman? Broadcasting legend Katie Couric (former co-host of NBC’s Today, CBS Evening News anchor and 60 Minutes correspondent) takes us on a unique journey to discover the dynamics and complexities of gender in our world. To better understand this complicated social and scientific issue, Couric crisscrossed the U.S. to talk with scientists, psychologists, surgeons, activists, authors and families to learn more about the role of genetics, brain chemistry and modern culture on gender fluidity. She also speaks with a number of ordinary people who find their bodies and their lives on the front line of a rapidly changing world. Examining the role of politics and culture on gender and with conversations that range from the scientifically enlightening to the deeply personal, Couric’s unflinching search for truth sheds light on countless untold stories of struggle, understanding, ignorance, hurt and love.