Description of Research Program
Summary of the projects Dr. Gutow's research group is pursuing.
EXPERIMENTAL RESEARCH AREA:
Behavior of coatings and molecular monolayers. We are studying self-assembled coatings (multi and monolayers) on solid substrates and films on water as model membranes. We do vibrational spectroscopy, atomic force microscopy (AFM), quartz crystal microbalance (QCM), X-ray flourescence (XRF), scanning electron microscopy (SEM), and contact angle measurements on these films.
Testing of potential anti-rhinovirals, which were identified by theoretical computations. This work involves cell culture and propagation of cold virus.
Ab initio calculations of molecular properties and interactions.
Contributions to the Jmol molecular visualization package: 1) development of the export to web function for automatic generation of interactive molecular visualization web pages/tutorials using Jmol; 2) debugging the GAMESS file reader; 3) Embedding Jmol in the Sage math package; 4) development of GUI for slicing objects in Jmol.
Addition of chemical intelligence to the the Sage math package, a cheminformatics project.
MINIMUM REQUIRED STUDENT EXPERIENCE:
PREFERRED STUDENT EXPERIENCE:
Quantitative analysis, one semester organic
CURRENT EXPERIMENTAL PROJECTS:
Growing hydroxyapatite (primarily calcium phosphate, like tooth enamal) layers. Presently optimizing conditions, using QCM to measure the mass depositied, XRF to check for deposition and atomic ratios, plus SEM and ATM to learn about the morphology of the layers.
Using the apatite layers as a binding layer between the surface and organic monolayer coatings, primarily species with phosphonic acid head groups.
Synthesis of phosphonic acid species to use for monolayer coatings. In particular, we are focusing on phosphonic acids with large multichain alkane tails.
Infrared microscopy of some of these monolayers to investigate homogeneity.
Studies of the behavior of the phosphonic acids as monolayers on the surface of water, using a Langmuir trough.
Reflection infrared spectroscopy of monolayers on the surface of water to investigate intermolecular interactions.
CURRENT ab initio PROJECTS:
Computation of vertical ionization potentials of medium size molecules of interest as drugs and drug degradation products.
Computation of protein ligand binding energetics and geometries.
SOME POSTER PRESENTIONS AT MEETINGS:
These projects have been supported by the National Science Foundation (CHE-0136844), the American Chemical Society Petroluem Research Fund (36594-B5), Research Corporation, the UW Oshkosh Faculty Development Program, the UW Oshkosh Student-Faculty Collaborative Program, the PFG scholars program, the Agilent Technologies ACT-UR program, and the WiSys Foundation.
Brandon Brummeyer (a former student) is presently working on both ab initio calculations aimed at understanding binding of rhinoviruses to cells and testing of the anti-rhinoviral properties of some compounds he previously identified. Before working on the virus project he also did some computations of vertical ionization potentials. Other students who have done research in my lab are: Brandon Brummeyer, Miguel Baldomero, Marissa Buzzanca, Gorman Stock, Ty Hetherinton, Demetria Dickinson, Liem Nguyen, Matt Farkas, Jessica Seefeldt, Brooke Koshel, Scott Vander Wielan, Nicole Kitzerow, Brendon Thompkins, Kim Hopsfensperger, Chris Potratz, Patrick Roach, Allan Stockinger, Katie Jensen, Jenny Dahl, Dustyn Sawall, Scott Zirngible, Brian Koeck, Jeremy Leveille, Mike Faley, Margaret Nguyen, Michael Phillips, Julie Wieland and Robert Kleisner.
B. L. Kedrowski, J. H. Gutow, G. Stock, M. Smith, C. Jordan, and D. S. Masterson, ”Glutathione reductase activity with an oxidized methylated glutathione analog”. J. Enz. Inh. Med. Chem. Online June 2013.
- R. J. Kleisner, B. H. Koeck, M. R. Phillips, J. A. Wieland, J. H. Gutow, V. Boiadjiev and W. T. Tysoe. "A System Based on Metal Alkyl Species that Forms Chemically Bound Organic Overlayers on Hydroxylated Planar Surfaces." Thin Solid Films 381(1), 10 (2001)
- V. Boiadjiev, A. Blumenfeld, J. Gutow and W. T. Tysoe. "Infrared and NMR Spectroscopic Studies of n-Alkanethiols Chemically Grafted on Dimethylzinc-Modified Silica Surfaces." Chem. Mater. 12(9), 2604 (2000).